There is an evidence gap with respect to the effectiveness of non-vascular surgeries over standard care for diabetic foot problems. Clinicians and researchers at the Lebanese American University Medical Centre decided to bridge this gap. The Evidence-based Diabetic Foot Research Centre was created, in order to conduct a series of evidence syntheses in the form of meta-analyses to evaluate the efficacy of available surgical procedures. The aim of this paper is to outline the evidence-based findings in relation to the outcomes of a number of surgical techniques in the treatment of diabetic foot disease, such as ulcers and ankle Charcot. The authors hope to encourage clinicians, particularly surgeons, to initiate primary and secondary research on the indications and usefulness of surgery when treating these difficult wounds.