<p>Lack of knowledge of and inadequate self-care are the most common reasons for patients with diabetes to develop a foot ulcer. This cross-sectional study aimed to examine the knowledge and self-care practice of diabetic foot patients. A sample of 100 patients was recruited from the diabetic outpatient clinic at Port-Said Governmental Hospital. The authors found that the majority of the patients taking part in the study displayed poor knowledge of diabetic foot care. Deficiencies included the inability to sense minor injuries (90%), proneness to ulceration (78%), and adverse effects of smoking on circulation (63%). Participants showed an intermediate level of self-care practice. Inability to see and move the foot was the biggest barrier to performing foot care (81%), followed by the inability to get nails cut independently (64%). Age and body mass index correlated with knowledge and self-care practice. While improper knowledge and self-care practice was prominent, health education is the solution to increasing patients’ self-care.</p>