<p>Malignancies that masquerade as chronic wounds often representsa conundrum for clinicians. This is particularly true of ulcers that have converted from benign lesions to cancers. These lesions, often referred to as Marjolin’s ulcers are uncommon yet, if undiagnosed, are often aggressive and metastatic. It therefore remains critical for clinicians to remain vigilant in performing biopsies on any lesions that appear clinically suspicious or fail to respond to appropriate disease specific treatment algorithms. The following article describes the pathophysiology of this condition and representative cases to aid clinicians in diagnosis and treatment.</p>