Severely infected wounds are challenging for clinicians and require a carefully considered management plan. Negative pressure wound therapy with instillation (NPWTi) can help as it can save time, effort and even patients’ lives. NPWTi is a modification of the conventional NPWT as an adjunctive treatment in the management of acute and chronic wound infections, combining the benefits of NPWT with the addition of controlled delivery of topical solutions (such as cleansers, antiseptics and antibiotics) to the wound bed (Kim et al, 2013). This case study examines the patient journey of an individual presenting with a range of symptoms after experiencing an insect bite. The patient was diagnosed with cellulitis, lymphangitis, skin ulcer, lymphadenitis, post-traumatic wound infection and necrotising fasciitis. The case illustrated the positive effects of NPWTi in terms of cleaning the wound and reducing pathogen bioburden.