Chronic wounds are a perennial problem in clinical practice and place a burden on patients, their families and healthcare providers. By addressing factors that contribute to chronicity (slough, biofilm, elevated levels of metalloproteinases and impaired angiogenesis), in addition to managing a patient’s comorbidities, nutritional status and lifestyle, there is a greater chance of healing. This article discusses the mechanisms by which UrgoClean Ag and UrgoStart support a healthy wound environment, along with two case studies of their use in practice.