MatriDerm^® (MedSkin Solution Dr. Suwelack) is an engineered dermal template developed to provide a one-step repair of full-thickness skin defects. It has been found to be effective in burn wounds, but not many reports are available for its usage to reconstruct other types of complex wounds. In this prospective study, the authors report on 2 years’ experience using Matriderm for the coverage of complex wounds. To the best of the authors’ knowledge, this is the first report from Kuwait focusing on the effectiveness of MatriDerm.