This study aims to describe the impact of diabetic foot ulcers (DFUs) on the quality of life (QoL) of individuals with diabetes. This descriptive multicentre study was conducted in 2013 in three Tunisian hospitals and included 60 patients with DFUs. Data were collected via the DFU Scale questionnaire. Respondents’ QoL deteriorated after developing a DFU, with 53.3% having low scores in almost all domains considered by the DFU Scale. The domains most affected related to emotion, finance, entertainment and daily activities. In addition to having functional consequences, DFUs significantly impair QoL and may impact family interactions and social function. Comprehensive care is needed to prevent DFUs and, when present, minimise their impact on QoL.