<p>Local infections are commonly associated with chronic pressure ulcers and necrotising fasciitis. The main objective in such wounds is to treat the infection either by maximising the host response systematically and/or by applying topical wound solutions locally. Negative pressure wound therapy (NPWT) with instillation was used with the following patient cases: three cases of sacral pressure ulcers, and one case of necrotising fasciitis. The surgeon used NPWT with instillation (of superoxidised solution) for all the cases. Regular patient follow-ups showed a significant reduction in the infection rates, which was a result of cleaning wound beds and closing them either by tertiary intention or leaving them to heal by secondary intention within few weeks.</p>